发明名称 |
NOVEL 6-SUBSTITUTED OXA- OR AZASTEROID COMPOUND |
摘要 |
<p>6-Substituted oxa- or azasteroid compounds represented by the formula <CHEM> have an excellent aromatase inhibition action, and are useful for prophylaxis or treatment of diseases caused by estrogens such as, for example, breast cancer, uterine cancer and prostatic hypertrophy. The characteristics of such a compound is that an oxygen or nitrogen atom is introduced in the D ring portion, and the 6-position of the steroid skeleton (substituent R<1>) is substituted with -S-R<2> wherein R<2> represents a hydrogen atom, a lower alkyl group, a cyano group or an acyl group; -O-R<3> wherein R<3> represents a hydrogen atom, a lower alkyl group or an acyl group; an azido group or an amino group.</p> |
申请公布号 |
EP0737689(A1) |
申请公布日期 |
1996.10.16 |
申请号 |
EP19950903001 |
申请日期 |
1994.12.20 |
申请人 |
TEIKOKU HORMONE MFG. CO., LTD. |
发明人 |
KOIZUMI, NAOYUKI;TAKEGAWA, SHIGEHIRO;IWASHITA, SHIGEKI TEIKOKU ZOKI SYATAKU;KAWACHI, TOMOKO;DOGUCHI, KOJI TEIKOKU ZOKI SYATAKU;HONMA, SEIJIRO;NAKAYAMA, MITSUYA TEIKOKU ZOKI RYO;MIEDA, MAMORU;TAKAHASHI, HIROO;SHIBATA, KENYU |
分类号 |
C07J73/00;(IPC1-7):C07J73/00;A61K31/56 |
主分类号 |
C07J73/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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