发明名称 |
Room temperature stable reagent semi-spheres |
摘要 |
A reagent semi-sphere is disclosed comprising at least one biological reagent and a glass forming filler material in a concentration sufficient to facilitate formation of a glassy, porous composition, wherein the reagent semi-sphere is room temperature stable, water soluble, and has a Tg above room temperature. A method is provided for making the reagent semi-sphere comprising providing an aqueous solution of a buffered biological reagent; mixing a glass forming filler material with the buffered reagent solution to form an emulsion wherein the concentration of the filler material is sufficient to facilitate formation of a glassy, porous composition having a predetermined semi-spherical shape; dispensing the emulsion in the form of substantially uniform droplets; collecting the droplets on an inert medium to form semi-spheres; and vacuum drying the droplets, under conditions suitable for maintaining the predetermined semi-spherical shape, to form the reagent semi-sphere; wherein the reagent semi-sphere is room temperature stable, water soluble, and has a Tg above room temperature.
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申请公布号 |
US5565318(A) |
申请公布日期 |
1996.10.15 |
申请号 |
US19940300015 |
申请日期 |
1994.09.02 |
申请人 |
PHARMACIA BIOTECH, INC. |
发明人 |
WALKER, DAVID W.;DIFRANCESCO, ROBERT A.;HEASTER, JEAN A.;JOLLY, JAMES F.;LIVELY, CHRIS R.;TREML, SUZANNE B. |
分类号 |
C12Q1/68;G01N33/531;G01N33/543;G01N33/548;(IPC1-7):C12Q1/00;C12Q1/37;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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