Azaaspartic acid analogs as interleukin-1 beta converting enzyme inhibitors

摘要

Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, alpha -substituted acetamides a <IMAGE> (A) wherein: R2=H or alkyl; R3=halo, O(CO)0-1 aryl, OPOR4R5; <IMAGE> where R4 and R5=aryl; R6=H, aryl or aralkyl; R7=independently selected from R6, CF3 and CF2CF3; R1=R6-CO, heteroaryl-CO, heteroaralkyl-CO and amino acid.