PRODUCTION OF 5-SUBSTITUTED HYDANTOIN COMPOUND

摘要

PURPOSE: To readily obtain the subject high-purity compound which IS a synthetic intermediate for amino acids, etc., useful as a medicine, etc., from an inexpensive raw material according to a new method for reacting a halogen- substituted hydantoin compound with an electrophilic or a nucleophilic agent. CONSTITUTION: A hydantoin compound of the formula (X is Cl, Br, etc.; R1 is H or a protecting group of N; R2 is H, a 1-8C alkyl, etc.) (preferably 5- chlorohydantoin, etc.) is reacted with an electrophilic or a nucleophilic agent except a phenol compound, preferably at 0-50 deg.C reactional temperature for 3-18hr reactional time. Specifically, e.g. the 5-chlorohydantoin is reacted with dimethyl malonate which is the nucleophilic agent to afford methyl hydantoin-5- malonate that is a synthetic intermediate for DL-aspartic acid. Furthermore, dioxane or acetic acid without containing water is preferred as a reactional solvent.