发明名称 |
PRODUCTION OF 2,2'-ANHYDRO-AND 2'-KETO-1-(3',5'-DI-O- PROTECTED BETA-D-ARABINOFURANOSYL)NUCLEOSIDE COMPOUND |
摘要 |
<p>A process for the preparation of compounds of the formula: <CHEM> wherein -Pg and R are protecting groups and B is a nucleobase. The process uses protected nucleobases to form 2,2'-anhydro nucleosides having the formula <CHEM> which are hydrolyzed to 2'-hydroxy intermediates which are then oxidized to the desired 2'-keto compounds. The compounds and intermediates are useful as antiviral and antitumor agents and as intermediates to 2,2'-anhydro-1-( beta -D-arabinofuranosyl)cytosine (anhydro-ara-C) and 1- beta -D-arabinofuranosylcytosine (Ara-C).</p> |
申请公布号 |
JPH08269082(A) |
申请公布日期 |
1996.10.15 |
申请号 |
JP19960062930 |
申请日期 |
1996.03.19 |
申请人 |
ELI LILLY & CO |
发明人 |
DAGURASU PATSUTON KUJIERU |
分类号 |
C07H1/00;A61K31/70;A61K31/7042;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7068;A61P31/12;A61P35/00;C07H19/04;C07H19/06;C07H19/067;C07H19/12;(IPC1-7):C07H19/067 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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