发明名称 |
Method of expanded porphyrin-oligonucleotide conjugate synthesis |
摘要 |
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-oligonucleotide conjugate. This method includes reacting derivatized nucleotides and a sapphyrin or a texaphyrin in a desired order in an automated or manual DNA synthesizer having a solid support to form a sapphyrin- or a texaphyrin-oligonucleotide conjugate.
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申请公布号 |
US5565552(A) |
申请公布日期 |
1996.10.15 |
申请号 |
US19950487722 |
申请日期 |
1995.06.07 |
申请人 |
PHARMACYCLICS, INC.;BOARD OF REGENTS, UNIV. OF TEXAS SYS. |
发明人 |
MAGDA, DARREN;SESSLER, JONATHAN L.;IVERSON, BRENT L.;SANSOM, PETRA I.;CROFTS, SHAUN P. |
分类号 |
A61K41/00;A61K47/48;A61K49/00;A61K49/06;A61K49/08;A61K51/04;A61L2/00;B01J31/06;B01J31/16;B01J31/18;C07D487/22;C07H21/00;C12N15/113;(IPC1-7):C07D487/22 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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