PROCESS FOR PREPARING PROPARGYL AMMONIUM CHLORIDE

摘要

FIELD: organic chemistry. SUBSTANCE: claimed process for preparing Z-isomers of propargyl ammonium chloride derivatives of general formula (I)comprises decomposing amine Z-isomer D-tartrate of general formula (II):and reacting the resulting amine Z-isomer of general formula (I) in the presence of base with halogenide of general formula (V) and subsequently reacting Z-isomer thus obtained of general formula (III):with hydrogen chloride in organic solvent wherein X is halogen atom; Y is hydrogen or fluorine atom, liberating amine base from amine Z-isomer D-tartrate of general formula (III) wherein Y is as defined above, in aqueous suspension with ammonium hydroxide or alkali metal salt and/or ammonium salt reacting it with 1-1.5 molar equivalents of halogenide of general formula (V) wherein X is as defined above at 0-50 C in buffer system having pH of 8-12 formed directly during amine liberation, and after aqueous layer is separated, extracting mixture containing amine Z- isomers of general formulae (II) and (III) in organic solvent with water and ammonium hydroxide/water and/or with aqueous phosphate salt solution having pH of 5.5- 7.5, dissolving amine Z-isomer of general formula (III) or salts thereof in aqueous layer and selectively separating it from amine Z-isomer of general formula (III) and converting amine Z-isomer of general formula (III) on completion of distillation into salt Z-isomer of general formula (I) using the prior ant process. EFFECT: more efficient preparation process.