17-ALKYLKETONESTEROIDS USEFUL AS INHIBITORS OF 5-α-REDUCTASE, INTERMEDIATE COMPOUNDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF PREPARING PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF STEROID-5-a-REDUCTASE IN MAMMALIAN

摘要

FIELD: organic chemistry, steroids. SUBSTANCE: invention relates to 17a- and 17b-alkylketone-3-carboxy-analogs of synthetic steroid compounds with aromatic ring A, to pharmaceutical compositions of indicated compounds for inhibition of isozyme 1 of steroid-5-a-reductase and isozyme 2 of steroid-5-a-reductase. Invention relates also to intermediate compounds and method of synthesis of these compounds. EFFECT: improved method of synthesis.