摘要 |
Compounds of formula (I), wherein R is a hydrogen atom or a carboxy, alkoxycarbonyl, -CO-NR4R5, -PO3H2 or -CH2OH radical, and R1 is an -alk-NH2, -alk-NH-CO-R3, -alk-COOR4, -alk-CO-NR5R6 or -CO-NH-R7 radical. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor also known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.
|
申请人 |
RHONE-POULENC RORER S.A.;ALOUP, JEAN-CLAUDE;AUDIAU, FRANCOIS;BARREAU, MICHEL;DAMOUR, DOMINIQUE;GENEVOIS-BORELLA, ARIELLE;HARDY, JEAN-CLAUDE;JIMONET, PATRICK;MANFRE, FRANCO;MIGNANI, SERGE;NEMECEK, PATRICK;RIBEILL, YVES |
发明人 |
ALOUP, JEAN-CLAUDE;AUDIAU, FRANCOIS;BARREAU, MICHEL;DAMOUR, DOMINIQUE;GENEVOIS-BORELLA, ARIELLE;HARDY, JEAN-CLAUDE;JIMONET, PATRICK;MANFRE, FRANCO;MIGNANI, SERGE;NEMECEK, PATRICK;RIBEILL, YVES |