| 摘要 |
<p>A subpopulation in the CD4+8+ (DP) thymic blast population is identified that is the precursor for thymic T cells. All such progenitors are c-kit+. The c-kit+ subset expresses lower levels of CD4 and CD8 than the large and small DP c-kit- cells. These DPint c-kit+ cells differentiate to thymic T cells rapidly on heterogenous thymic stromal cell cultures. Similar maturation takes place in vivo over 4 days.</p> |
