发明名称 |
Psoralen conjugated methylphosphonate oligonucleotides as therapeutic agents for chronic myelogenous leukemia |
摘要 |
Novel reagents which are useful for conjugating a psoralen moiety to an oligomer having at least one non-nucleotide monomeric unit are provided. Also provided are psoralen-conjugated oligomers. Psoralen-conjugated oligomers complementary to the abl gene or bcr/abl of chimeric mRNA are useful in decreasing expression of abl-associated tyrosine kinase and P210 protein. |
申请公布号 |
AU5618096(A) |
申请公布日期 |
1996.10.10 |
申请号 |
AU19960056180 |
申请日期 |
1996.06.25 |
申请人 |
GENTA INCORPORATED |
发明人 |
MORTEZA MONIR;MARK ALAN REYNOLDS;LYLE J. ARNOLD JR. |
分类号 |
A61K48/00;A61P35/02;C07D493/04;C07H21/00;C07H21/02;C07K14/47;C07K14/82;C12N15/09;C12N15/113;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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