发明名称 |
INHIBITION OF TAU-TAU-ASSOCIATION |
摘要 |
The present invention relates to novel methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association and pathological neurofilament aggregation. The methods of the present invention are particularly useful in screening substances for the prophylaxis and treatment of Alzheimer's disease, motor neuron disease, Lewy body disease, Pick's disease and progressive supranuclear palsy. In addition, substances capable of selectively inhibiting pathological aggregates while preserving normal cytoskeletal function are described.
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申请公布号 |
WO9630766(A1) |
申请公布日期 |
1996.10.03 |
申请号 |
WO1996EP01307 |
申请日期 |
1996.03.25 |
申请人 |
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发明人 |
WISCHIK, CLAUDE, MICHEL;EDWARDS, PATRICIA, CAROL;HARRINGTON, CHARLES, ROBERT;ROTH, MARTIN;KLUG, AARON |
分类号 |
G01N33/53;A61K31/54;A61K31/5415;A61P25/28;C07D279/20;C07K14/47;G01N33/15;G01N33/50;G01N33/531;G01N33/543;G01N33/566;G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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