PIPERIDINE DERIVATIVES

摘要

Piperidine derivatives represented by general formula (I) or pharmaceutically acceptable acid addition salts thereof: wherein n represents an integer of 0 or 1; X represents CH2, O or CH-CH3; R represents hydrogen, halogeno, lower alkyl, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, substituted aminosulfonyl or nitro; and R1 and R2 may be the same or different and each represents hydrogen or lower alkyl. The compound has an antagonism on Substance P and is useful as a preventive or remedy for asthma, vomitting, etc.