| 发明名称 |
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE |
| 摘要 |
The present invention comprises peptidomimetic compounds which comprise a suitably aniline and aminoalkylbenzene moieties. The instant compounds inhibit the farnesyl-protein transferase enzyme and the farnesylation of certain proteins. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesylprotein transferase and the farnesylation of the oncogene protein Ras.
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| 申请公布号 |
CA2216526(A1) |
申请公布日期 |
1996.10.03 |
| 申请号 |
CA19962216526 |
申请日期 |
1996.03.25 |
| 申请人 |
MERCK & CO., INC.;MERCK & CO., INC. |
发明人 |
STOKKER, GERALD E.;CICCARONE, TERRENCE M.;DINSMORE, CHRISTOPHER J.;WAI, JOHN SUIMAN;WILLIAMS, THERESA M. |
| 分类号 |
C07D521/00;A61K31/135;A61K31/165;A61K31/40;A61K31/403;A61K31/4035;A61K31/404;A61P35/00;A61P43/00;C07C323/25;C07C323/60;C07D209/08;C07D209/46;(IPC1-7):C07C323/25;C07D403/00;C07D405/00;C07D409/00;C07D413/00;C07D417/00;C07D471/04;C07D495/04;C07C321/10;A61K31/13;C07D217/14;C07D223/16;A61K31/16;A61K31/27;A61K31/275;A61K31/325 |
主分类号 |
C07D521/00 |
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