| 摘要 |
An effective treatment and prophylaxis for onychomycosis is described involving the regular topical application of an antifungal agent dissolved in a dimethyl sulfoxide solution to the nail and to the nail's epinychium. The antifungal agent is present in the composition in at least a minimum inhibitory concentration for the antimycotic agent for the particular fungus when the antifungal agent is dissolved in DMSO. The composition may be applied to the nail and epinychium on a daily or less frequent basis, and the infected nail need not be removed. Also described are methods of treating or preventing onychomycosis, associated pharmaceutical compositions for treating or preventing onychomycosis (especially ones containing dimethyl sulfoxide and from 2 to 10 % by weight griseofulvin), and methods of making the pharmaceutical compositions.
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