BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS

摘要

Compounds of formula (I), wherein X represents a single bond, O, S or CR<9>R<10> where R<9> and R<10> each independently represent a hydrogen atom or a C1-4alkyl group; R<1a>, R<1b> and R<1c> each independently represent a substituent selected from: a hydrogen or halogen atom, a hydroxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4alkoxyC1-4alkyl, C3-6cycloalkylC1-4alkoxy, C1-4alkanoyl, C1-4alkoxycarbonyl, C1-4alkylsulphonyl, C1-4alkylsulphonyloxy, or C1-4alkylsulphonylC1-4alkyl, arylsulphonylarylsulphonyloxy or arylsulphonylC1-4alkyl group, or a group R<11>OCO(CH2)p, R<11>R<12>NCO(CH2)p or R<11>R<12>NSO2(CH2)p where each of R<11> and R<12> independently represents a hydrogen atom or a C1-4alkyl group and p represents zero or an integer from 1 to 4; R<2>, R<3>, R<4> and R<5> each independently represent a hydrogen atom or a C1-4alkyl group; R<6> represents a hydrogen atom or a C1-6alkyl, C3-6alkenyl or arylC1-4alkyl group; R<7> represents a hydrogen atom or a C1-4alkyl group; and R<8> represents a group of structure (a), (b) or (c) and salts thereof are useful in therapy, as modulators of D3 receptors, in particular as antipsychotic agents.