IMPROVED SYNTHESIS OF TYROSINE-DERIVED DIPHENOL MONOMERS

摘要

A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with an L-tyrosine ester in a watermiscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a waterimmiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also disclosed.