N-alkylpipecolic acid compounds, their preparation and use in the synthesis of levobupivacaine and analogues

摘要

Optically-enriched N,O-dialkyl pipecolates are useful in the preparation of levobupivacaine and related analgesics. They may be prepared simply by dialkylating optically-enriched pipecolic acid by reaction with an alkylating agent, in the presence of base and a polar aprotic solvent.