| 摘要 |
Disclosed are organo phosphonic acids having the formula: where:- n = 0 or 1 R 1 = H or R 3 = an alkyl group containing > 10 carbon atoms R 4 = H or CH 3 that provide improved bio-availability of drugs and nutrients by permiabilising cell membranes. They may also be used for nanoencapsulation of drugs and for improving pigment absorption in aqua-cultures. Also disclosed is a method for preparing organo phosphonic compounds comprising reacting an acid chloride of long chain aliphatic acid (eg having 10-20 carbon atoms) with an alkyl phosphonic acid derivative containing an active amino or hydroxy group in a non-aqueous medium at low temperatures (eg in chloroform at temperatures below 5{C). Especially useful are the reaction products of palmitoyl or lauroyl chloride with ethane-1-hydroxy-1,1-diphosphonic acid, 2-amino-ethyl phosphonic acid or 1 amino-ethyl phosphonic acid. |
