摘要 |
A novel thielocin derivative having a phospholipase A2 inhibitory activity, represented by general formula (I), or a salt thereof, wherein R<1> to R<8> represent each independently hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; E1 and E2 represent each independently hydrogen or an ester residue; m and n represent each independently an integer of 0 to 4; and -Y- represents a divalent group selected among those represented by the following formulae -CH2CH2-, -CH = CH-, (II), (III), (IV), (V), (VI), (VII). <CHEM> |
申请人 |
SHIONOGI & CO., LTD., OSAKA, JP |
发明人 |
OHTANI, MITSUAKI, NARA-SHI NARA 630, JP;MATSUTANI, SHIGERU, HASHIMOTO-SHI WAKAYAMA 648, JP;YOSHIDA, TADASHI, TOYONO-GUN OSAKA 563-01, JP;TANAKA, KAZUSHIGE SHIONOGI SEIYAKU TERAE-RYOU, AMAGASAKI-SHI HYOGO 660, JP;FUJII, YASUHIKO, KITA-KU KOBE-SHI HYOGO 651-15, JP;SHIRAHASE, KAZUHIRO, NEYAGAWA-SHI OSAKA 572, JP |