| 摘要 |
<p>A process for the preparation of a 2-substituted-3,3-difluorofuran using diethyl ammonium sulfur trifluoride (DAST) and pyridine hydrogen fluoride. The process is particularly useful for producing a 2',2'-difluoronucleoside, particularly 1-(2',2'-difluoro- beta -D-arabinofuranosyl)cytosine (also known as 2'-deoxy-2',2'-difluorocytidine), a known antiviral and antitumor agent.</p> |
