摘要 |
Cytotoxically effective pharmaceutical which contains compounds of formula I R - Y - PO? - X - R1 or a physiologically compatible salt thereof, where in formula I R is a saturated or unsaturated hydrocarbon radical having from 12 to 24 carbon atoms, which can also be halogen substituted, X is an oxygen atom, NH or NR2 and Y is an oxygen atom or NH, R1 is a C1-C8-alkyl group, or where R1 is a C2-C8-alkyl group, which is unsaturated and/or is substituted with halogen, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyl or phenyl, and where R1 can also be 2-tert.-butyloxycarbonyl-aminoethyl, 2-tert.-butyloxycarbonylethyl, 2,3-isopropyidene-dioxi-propyl-(1), 2,3-dibenzyloxy-propyl-(1), 1,3 -dibenzyl-oxy-propyl-(2) or N-C1-C6-alkylamino-C2-C6-alkyl, when X is an oxygen atom and where R1 additionally can be 2,3-dihydroxy-propyl-(1), when X is the NH group, and R2 is a 2,3-dihydroxy-propyl-(1) group, a C1-C8-alkyl group or a C2-C8-alkyl group, which is unsaturated and/or is substituted with halogen, amino, C1-C6-alkylamino, di-C1C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyl or phenyl, compounds of formula I as well a process for their preparation. |