| 摘要 |
<p>A description is given of a process for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetonitrile (II) with an alkaline (alkali metal) haloacetate, treatment of 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) with D-(-)-N-methylglucamine, with second-order asymmetric transformation, hydrolysis of the D-(-)-N-methylglucamine salt of (-)-3-cyano-3-(3,4-dichlorophenyl)propionic acid and reduction of the laevorotatory (levorotatory) cyanoacid thus obtained with a borane under conditions which preserve chirality.</p> |
