DOMAIN I OF PROTEASE INHIBITOR, DNA, VECTOR, CELL, METHOD OF PROTEASE INHIBITOR PREPARING, PHARMACEUTICAL COMPOSITION, THE USE OF DOMAIN I

摘要

FIELD: biochemistry, molecular biology. SUBSTANCE: variant of domain I of human protease inhibitor of Kunitz type has the following amino acid sequence: X-Cys-Ala- -Phe-Lys-Ala-Asp-X-Gly-X-Cys-X, X, X, X, X, X-Phe-Phe-Phe-Asn-Ile-Phe- -Thr-Arg-Glu-Cys-Glu-Glu-Phe-X-Tyr-Gly-Gly-Cys-X, X, X-Gln-Asn- -Arg-Phe-X-Ser-Leu-Glu-Glu-Cys-X, X-Met-Cys-Thr-Arg-X(sequence D N1) where Xmeans H or 1-7 natural amino acid residues for exception Cys; every of X-Xindependently means natural amino acid residue and Xmeans OH or 1-5 natural amino acid residues for exception Cys; condition: at least one of amino acid residues X-Xdistincts of the corresponding amino acid residue of natural sequence. EFFECT: improved method of inhibitor preparing.