THIO-SUBSTITUTED CYCLIC PHOSPHONATE COMPOUNDS FOR TREATMENT OF ANOMAL CALCIUM AND PHOSPHATE METABOLISM, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT

摘要

FIELD: organic chemistry. SUBSTANCE: invention relates to thio-substituted cyclic phosphonate compounds among them bis-phosphonates, phosphoalkyl-phosphonates, phosphonocarboxylates and phosphonosulfonates and to their pharmaceutically acceptable salts and esters also. Invention relates to the pharmaceutical compositions containing safety and effective amount of proposed compound and pharmaceutically acceptable filling agents. Then, invention relates to the method of treatment or prophylaxis of pathological states exhibiting anomal calcium and phosphate metabolism in human and other mammalian among them for treatment and prophylaxis of osteoporosis and arthritis. Method involves administration of safety and effective amount of proposed compound or composition to human or other mammalian. These compounds can be monocyclic or bicyclic and show the following general formula: (I)where at least one of substituents R, Rand Rmeans SRor RSR. EFFECT: improved method of synthesis, enhanced effectiveness.