ONE-POT ENZYMATIC SULFATION PROCESS USING 3'-PHOSPHOADENOSINE-5'-PHOSPHOSULFATE AND RECYCLED PHOSPHORYLATED ADENOSINE INTERMEDIATES

摘要

A process for the enzymatic synthesis of sulfate esters is disclosed in which intermediate phosphorylated adenosine compounds are recycled to minimize enzyme inhibition. Exemplary enzymes include ATP sulfurylase, APS kinase and a sulfotransferase.