| 摘要 |
<p>The present invention relates to compounds of formula (I), wherein R?1 and R4¿ represent hydrogen, halogen, C¿1-6?alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C1-6alkoxy, C1-4alkyl substituted by a hydroxy or C1-4alkoxy group, OCF3, hydroxy, trifluoromethyl, trimethylsilyl, nitro, CN, SR?a, SORa, SO¿2R?a, CORa, CO¿2Ra or CONRaRb, where R?a and Rb¿ are each independently hydrogen or C¿1-4?alkyl; R?2, R3 and R5¿ represent hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy substituted by a C1-4alkoxy group, or trifluoromethyl; R?6¿ represents C¿1-6?alkyl, optionally substituted by oxo, substituted by a 5-membered heteroaromatic ring selected from oxazole, thiazole, isoxazole, isothiazole, oxadiazole and thiadiazole, wherein each heteroaromatic ring is substituted at the available carbon atom by a group of the formula: ZNR?7R8¿. The compounds are of particular use in the treatment of pain, inflammation, migraine and emesis.</p> |
