A METHOD OF CREATING STANDARDIZED SPECTRAL LIBRARIES FOR ENHANCED LIBRARY SEARCHING

摘要

A method of creating a library of standardized spectral data and identifying a sample by searching the standardized library for a match with the sample spectrum is disclosed. This method provides enhanced library searching capabilities. A method of correcting for instrumental changes that influence the spectral response of a mass spectrometer over time is also disclosed. The methods entail determining and applying a transfer function which equalizes instrument bias between instruments and within the same instruments over time. A transfer function is specific to a particular instrument, and is based on the relationship between a reference spectrum of a standard as stored in a library and a spectrum of the standard obtained on the particular instrument of interest.