摘要 |
<p>The invention includes a nucleic acid encoding a nuclear localization protein from Drosophila, timeless or TIM, which binds to, stabilizes and translocates to the nucleus a protein involved in circadian rhythms. Also included are the protein encoded by the nucleic acid, antibodies to the protein, and compositions and kits for the diagnosis and treatment of disorders related to the sleep-wake cycle.</p> |