BIOCOMPATIBLE MATERIALS

摘要

A biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provide an improved nonthrombogenic surface relative to the substrate without the phospholipid moiety covalently attached thereto is provided. In particularly preferred embodiments, the bicompatible material has structure (1) wherein R<1> is a (C1-C30)alkyl group; R<2> is a (C1-C30)alkylene group; m is 1-4; n is 1-4; and L is a divalent linking group covalently bonded to the substrate and to the phospholipid moiety.