发明名称 |
PROCESS FOR THE PREPARATION OF 2,2'-ANHYDRO- AND 2' -KETO-1-(3', 5'-DI-O-PROTECTED-.BETA.-D-ARABINOFURANOSYL) NUCLEOSIDES |
摘要 |
<p>A process for the preparation of compounds of the formula: wherein -Pg and R are protecting groups and B is a nucleobase. The process uses protected nucleobases to form 2,2'-anhydro nucleosides having the formula which are hydrolyzed to 2'-hydroxy intermediates which are then oxidized to the desired 2'-keto compounds. The compounds and intermediates are useful as antiviral and antitumor agents and as intermediates to 2,2'-anhydro-1-(.beta.-D-arabinofuranosyl)cytosine (anhydro-ara-C) and 1-.beta.-D-arabinofuranosylcytosine (Ara-C).</p> |
申请公布号 |
CA2171518(A1) |
申请公布日期 |
1996.09.25 |
申请号 |
CA19962171518 |
申请日期 |
1996.03.11 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
KJELL, DOUGLAS PATTON |
分类号 |
C07H1/00;A61K31/70;A61K31/7042;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7068;A61P31/12;A61P35/00;C07H19/04;C07H19/06;C07H19/067;C07H19/12;(IPC1-7):C07H19/06 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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