Materials and methods relating to the diagnosis and prophylactic and therapeutic treatment of papillary renal cell carcinoma

摘要

The present invention relates to materials and methods for the diagnosis, prophylactic and therapeutic treatment of papillary renal cell carcinoma. It has been found that the t(X;1) translocation found in papillary renal cell carcinoma results in the fusion of the TFE3 transcription factor gene to various other fusion partners. Therefore, the present invention allows the identification of a characteristic fusion product comprising a TFE3 sequence associated with a fusion partner.