Cyano-alpha-amino carboxylic acids, and their use in preparing labelled alpha-amino acids

摘要

The present invention provides a labeleed beta -cyano-L-alanine and a gamma -cyano- alpha -aminobutyric acid, of which cyano group carbon is labelled with radionuclide <11>C or <14>C, or stable isotope <13>C. The present invention also provides a labelled amino acids such as asparagine, asparatic acid, DABA, GABA, glutamine and glutamic acid synthesized by using the labeleed beta -cyano-L-alanine and the gamma -cyano- alpha -aminobutyric acid as an intermediate. The labelled amino acids are useful for in vivo imaging of tumors and brain functions.