| 摘要 |
PURPOSE: To obtain the subject new antibody specifically reacting with a new neurophysin having a specific amino acid sequence, capable of detecting the presence of the neurophysin in a brain, and useful for researching the functions of the brain, and for diagnosing Alzheimer's disease, epilepsy, etc. CONSTITUTION: A new antibody against neurophysin, specifically reacts with a new neurophysin having an amino acid sequence containing an amino acid sequence of the formula, can detect the presence of the neurophysin in a brain, gives a hint for the clarification of the functions of the brain, namely a memorizing mechanism or a learning mechanism, and is further useful for solving regressive diseases such as Alzheimer's disease, the function deficiency or immune deficiency of the brain, such as epilepsy, etc. The antibody is obtained by mixing the neurophysin prepared by a genetic engineering means with the same amount of a Freund's perfect adjuvant, subcutaneously injecting the mixture into a rabbit to immunize the rabbit, further injecting the antigen into the rabbit five times for each week, gathering blood from the aural arteria of the rabbit, centrifuging the gathered blood, and subsequently separating an IgG fraction from the centrifuged anti-serum. |
