THERAPY OF HYPERTENSION AND CONGESTIVE CARDIAC INSUFFICIENCY

摘要

PROBLEM TO BE SOLVED: To obtain a composition for the treatment of hypertension and congestive heart failure, containing a specific angiotensin II antagonist and a selective or dual-acting neutral endopeptidase inhibitor. SOLUTION: This composition contains (A) an angiotensin II antagonist, 2-butyl-6,7,8,9-tetrahydro-3- [2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3- diazaspiro[4.4]nonan-4-one, and (B) a selective neutral endopeptidase inhibitor or a dual-acting neutral endopeptidase inhibitor. The component B includes a selective inhibitor of formula I [R1 is OH, a 1-7C alkoxy, etc.; R2 is a 1-7C alkyl, phenyl, etc.; R3 is H, a 1-7C alkyl, etc.; (n) is 1-15], and a dual-acting inhibitor of formula II [(p) is 1, 2; (m) is 0, 1; X is O, S; Y is CH2 , S, O; R4 is H, a 1-7C alkyl, etc.].