发明名称 |
Tumor suppressor gene |
摘要 |
A detailed genetic map on human chromosome 11 was prepared. Then, a commonly deleted region on the chromosome in the tumor tissues of patients with multiple endocrine neoplasia type 1 was identified. Further, by linkage analysis of a family line with this disease, a genetic cause for this disease was localized. A gene present in the region common to these observations was cloned and the structure of this gene was determined. Because a protein coded by this DNA is homologous with those of transcriptional factors, it is expected that the above-mentioned gene may be a novel tumor suppressor gene. Further, it is also expected that the above-mentioned gene and a protein coded for thereby may be useful in preparation of a remedy for cancer and a diagnostic drug for cancer.
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申请公布号 |
US5559023(A) |
申请公布日期 |
1996.09.24 |
申请号 |
US19950384850 |
申请日期 |
1995.02.07 |
申请人 |
CANCER INSTITUTE;EISAI CO., LTD. |
发明人 |
NAKAMURA, YUSUKE;IMAI, TAKASHI |
分类号 |
A61K38/00;C07K14/47;C07K14/82;(IPC1-7):C12N5/10;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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