GRANULAR RESIN MATERIAL, MEDICAL MATERIAL AND MEDICINAL PREPARATION CONTAINING SAME RESIN MATERIAL

摘要

PURPOSE: To obtain a granular resin material capable of sustainedly releasing only the necessary amount of cilostazol over a long period into a living body without causing any adverse effect such as a headache by blending the specific amount of cilostazol with the copolymer of ethylene/vinyl alcohol. CONSTITUTION: This granular resin material having <=2000μm (especially preferably 75-105μm) particle diameter is prepared by blending (A) a ethylene/vinyl alcohol copolymer having a high safety and stability to a living body, 44-47mol% ethylene content, 12000-40000 number averaged molecular weight and 160-175 deg.C melting point with (B) 5-90wt.% (most preferably 60-85wt.%) cilostazol. Furthermore, cilostazol exhibits a high suppressing effect for platelet aggregation and also has an inhibiting effect to phosphodiesterase, an antiulcer effect, a hypotensive effect, an antiphlogistic effect, etc.