VACCINE COMPOSITION, METHOD OF IMMUNE SYSTEM STIMULATION

摘要

FIELD: medicine, virology. SUBSTANCE: invention provides vaccine compositions of attenuated respiratory-syncytial virus (RSV). Moreover, attenuated virus can be derivative of RSV which was partially attenuated by passage in the cold or by mutations insertion that make virus showing phenotype sensitive to temperature (ts) or adapted to cold (ca). Invention provides methods of individual immune system stimulation for inducing protection against respiratory-syncytial virus by administration of attenuated RSV. Invention provides also pure cultures of attenuated RS virus in which this virus is attenuated more completely by the further derivatization (derivatives preparing) early identified as noncomplete attenuated mutants ts and cp. EFFECT: improved method of stimulation.