发明名称 |
PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF CLAVULANIC ACID |
摘要 |
A process for preparation of a pharmaceutically acceptable salt of clavulanic acid comprising the steps of: removing solids from a clavulanic acid containing fermentation broth by microfiltration; acidifying the filtrate to a pH between 1 and 3; extracting the acidified filtrate with a water immiscible solvent and separating the clavulanic acid containing extract; mixing the extract with a metal donor and at least one additional solvent; and separating the metal clavulanate salt from the solution.
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申请公布号 |
WO9628452(A1) |
申请公布日期 |
1996.09.19 |
申请号 |
WO1996GB00558 |
申请日期 |
1996.03.11 |
申请人 |
LEK PHARMACEUTICAL AND CHEMICAL CO. D.D.;CAPUDER, EGIDIJ |
发明人 |
CAPUDER, EGIDIJ |
分类号 |
C07D503/00;C07D503/18;C12P17/18;(IPC1-7):C07D503/18 |
主分类号 |
C07D503/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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