A biodegradable implant for placement in nonunion bone fractures as a substitute for bone graft material is provided which is a flat plate or disk having a thickness of between about 1 mm and about 15 % of the length of the bone, interconnected micropores, and canals substantially equivalent in size and spacing to naturally-occurring Haversian canals. The implant may additionally comprise additives such as growth factors, including bone morphogenic protein. In a preferred embodiment the implant is formed from a biodegradable polymer such as a polylactic acid-polyglycolic acid copolymer by a gel casting technique followed by solvent extraction to precipitate the implant as a microporous solid.
申请公布号
WO9628117(A1)
申请公布日期
1996.09.19
申请号
WO1996US00559
申请日期
1996.01.16
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;BOYAN, BARBARA, D.;AGRAWAL, CHANDRA, M.;HECKMAN, JAMES, D.
发明人
BOYAN, BARBARA, D.;AGRAWAL, CHANDRA, M.;HECKMAN, JAMES, D.