Novel biphenyl derivatives or salts thereof, and anti-inflammatory agents containing the same

摘要

Biphenyl derivatives represented by general formula (1), or salts thereof which have excellent anti-inflammatory, antipyric/analgesic and antiarthritic effects and thus are useful as medicines, wherein R<1> represents lower alkyl, aryl or amino; R<2> represents aryl or -Z-R<5> (wherein R<5> represents alkyl, alkenyl, alkylsulfonyl, aryl, etc; and Z represents oxygen, sulfur, imino, etc.); R<3> and R<4> represent each hydroen, halogeno, cyano, azido, nitro, amino, carboxy, hydroxy, acyl, alkoxycarbonyl, alkyl, alkenyl, alkoxy, alkylthio, etc.; and n is 0, 1 or 2.