| 摘要 |
A library of isolated and purified antigens specific for a micro organism is a set of individual molecules. The library forms antigen-antibody complexes useful in the context of diagnosing, vaccinating, treating conditions or diseases accociated with a specific microorganism such as Helicobacter pylori-induced gastroduadenal disease. For the antigen-antibody complexes in question the antibody is an immunoglobulin, which is IgE if the antigens are allergens. Complexes with IgA, IgG and IgM also are useful for monitoring progression of the disease and therapy effectiveness and selecting antigens for use in a customized vaccine. By this multivariate approach, a specific condition is diagnosed with high sensitivity and specificity by determining whether complexes form between a specific antigen library and a biological sample which contains immunoglobulins from an individual. In addition, such libraries are useful for immunotherapy, particularly with respect to antigen desensitization and to production of customized vaccines. |
