2-Penem compounds, a method for their preparation and pharmaceutical compositions comprising them.

摘要

The present invention relates to 2-penem compounds of the formula <CHEM> wherein R is lower alkyl, aminoloweralkyl, mono- or diloweralkylaminoloweralkyl, acylaminolowerallyl, aralky, heteroaralkyl, hydroxyloweralkyl, hydroxyaralkyl, carboxyloweralkyl or alkoxycarbonylloweralkyl; R1 is hydrogen, lower alkyl, aralkyl or a group of the formula: R6 CHOH- with R6 being hydrogen, lower alkyl, aralkyl, heteroaryl, heteroaralkyl, hydroxyaralkyl or aryl; R2 is hydrogen or methyl; and X is cyano, tetrazol-5-yl, -COOR3 or -CONR4R5 wherein R3 is hydrogen, an alkali metal cation, phthalidyl or a pivaloyloxymethyl group; and R4 and R5 are independently hydrogen or lower alkyl; with the proviso that when X is -COOR3 both R1 and R2 cannot be hydrogen; to pharmaceutical compositions comprising such compounds and methods for preparing them.