发明名称 |
Hematopoietic stem cell specific gene expression |
摘要 |
The subject application relates to a hematopoietic stem cell specific promoter and to a hematopoietic stem cell specific enhancer and to uses therefor. The invention also includes a hematopoietic stem cell specific promoter-heterologous gene construct, where the expression of the heterologous gene is under the control of the myeloid cell type specific promoter. Additionally, the application is drawn to a method of expressing a heterologous gene in a hematopoietic stem cell. The invention further includes a method of expressing a selected heterologous gene product in hematopoietic stem cells in an individual. The invention also includes a transgenic non-human mammal in which the hematopoietic stem cells express a protein encoded by a heterologous gene. Finally the invention includes a method for identifying factors which can regulate hematopoietic stem cell specific transcription.
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申请公布号 |
US5556954(A) |
申请公布日期 |
1996.09.17 |
申请号 |
US19920990965 |
申请日期 |
1992.12.15 |
申请人 |
BETH ISRAEL HOSPITAL BOSTON ASSOCIATION |
发明人 |
BURN, TIMOTHY C.;SATTERTHWAITE, ANNE B.;TENEN, DANIEL G. |
分类号 |
C07K14/705;C12N15/85;(IPC1-7):C07H21/04;C12N5/10 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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