| 摘要 |
<p>This invention provides medical compositions containing an aldose reductase inhibitory, spirolinked pyrrolidine-2,5-dione of the formula:
<CHEM>
wherein Ra, Rb, Rc and Rd are hydrogen or alkyl, or, together with the adjacent ring carbon atoms, form a benzene or pyridine ring B; rings A and B bear 1 or 2 optional substituents; and X is oxygen, sulphur, sulphinyl, sulphonyl, methylene, alkylimino, phenylimino or benzylimino, or, when Ra, Rb, Rc and Rd are hydrogen or alkyl, X is imino; or a pharmaceutically acceptable salt thereof; or a non-toxic biodegradable precursor thereof.
<??>The invention also provides novel compounds of formula I and processes for their manufacture. The compositions are useful in the treatment or prophylaxis of the side-effects of diabetes or galactosemia. </p> |
