摘要 |
Prodn. of aerosols in which drug particles are microencapsulated with at least a monolayer of a hydrophobic substance (I) is effected by (a) generating an aerosol stream comprising drug particles in air saturated with water vapour at a preselected temp., (b) generating a stream of gaseous (I) in air satd. with water vapour at the same temp. as in (a), (c) turbulently mixing the two streams, and (d) cooling the mixed stream. A vessel (2) contg. the encapsulating substance, e.g. a fatty acid or fatty alcohol, is immersed in a water bath (3) at a temp. 3 degrees C above the m.pt. of the substance. A humidified air stream (4) is passed through the vessel and into a ring-gap mixer (5) for mixing with drug aerosol. The mixer is also heated by the water bath via PVC tubing (10). The aerosol-conditioning section (9) is heated by a jacket supplied with water from the PVC tubing and is lined with moistened filter paper (8). The condenser (11) is maintained at 15 degrees C. |
申请人 |
GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH, 85764 OBERSCHLEISHEIM, DE |
发明人 |
SEEMANN, STEFAN, 82467 GARMISCH-PARTENKIRCHEN, DE;HEYDER, JOACHIM, PROF. DR., 80802 MUENCHEN, DE;NIESNER, REINHARD, PROF. DR., 78532 TUTTLINGEN, DE |