发明名称 |
Methods for the production of conformationally stabilized cell adhesion peptides |
摘要 |
<p>Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides. <IMAGE></p> |
申请公布号 |
EP0731110(A1) |
申请公布日期 |
1996.09.11 |
申请号 |
EP19950250301 |
申请日期 |
1988.12.08 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
PIERSCHBACHER, MICHAEL D.;RUOSLAHTI, ERKKI I. |
分类号 |
A61L27/00;A61K38/00;B31B1/06;B65H3/06;B65H7/18;C07K1/02;C07K5/08;C07K5/10;C07K7/06;C07K7/08;C07K7/56;C07K14/00;C07K14/47;C07K14/705;C07K14/78;(IPC1-7):C07K14/75;C12N5/00 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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