| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I [R<1> and R<2> are H or OH protecting group; R<3> is 5-25C monovalent aliphatic hydrocarbon group or NR<4>R<5> (R<4> is 5-25C monovalent aliphatic hydrocarbon group; R<5> is H or monovalent aliphatic hydrocarbon); A is 2-16C bivalent aliphatic or bivalent aromatic hydrocarbon group or bivalent aromatic heterocycle group; either one of X and Y is NR<6> and the other is O, S or NR<7> (R<6> and R<7> are H or lower alkyl); (n) is 1-4]. EXAMPLE:N-[4-(Oleoyloxy)phenyl]-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4 -carbonyl) amino]propaneamide. USE:An acyl CoA-cholesterol acyl transferase inhibitor. A medicine having an action to lower lipid in blood and anti-arteriosclerosis action based on the inhibition of cholesterol absorption together. PREPARATION:For example, a compound expressed by formula II (R<11> and R<21> are OH protecting group) is subjected to a reaction with a compound expressed by the formula R<3>-COZ<1> (Z<1> is OH, halogen, etc.) or compound expressed by the formula R<4>-NCO to provide the compound expressed by formula I.</p> |
