| 摘要 |
PCT No. PCT/GB93/02213 Sec. 371 Date Apr. 27, 1995 Sec. 102(e) Date Apr. 27, 1995 PCT Filed Oct. 27, 1993 PCT Pub. No. WO94/10167 PCT Pub. Date May 11, 1994 <IMAGE> (I) Compounds of formula (I), wherein Q1 represents an aryl group; the dotted line represents an optional covalent bond; one of X and Y represents H and the other represents hydroxy or C1-6alkoxy, or X and Y together form a group =O or =NOR5 where R5 is H or C1-6alkyl; Z represents O, S or NR2, where R2 is H or C1-6alkyl; W represents a bond or a saturated or unsaturated hydrocarbon chain of 1, 2, 3, 4, 5 or 6 carbon atoms; R1 represents H or C1-6alkyl. R3 represents H, C1-6alkyl or C2-6alkenyl; R4 represents an optionally substituted phenyl group; and R6 represents a specified amino group or an optionally substituted aromatic or non-aromatic azacyclic or azabicyclic group; and salts and prodrugs are tachykinin receptor antagonists.
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