PEPTIDE DERIVATIVES, METHOD OF SYNTHESIS, PHARMACEUTICAL COMPOSITION, TREATMENT METHOD

摘要

FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: peptide derivative of the formulawhere: R- hydrogen atom or lower alkyl; R- lower alkyl or halogen atom; R- hydrogen atom, lower alkyl or halogen atom; R- lower alkyl; R- ar(lower)alkyl; R- amino-group or, optional, substituted hydroxyl-group and X - oxygen, sulfur atom or group Rwhere Rmeans N,N-di(lower)alkylamino(lower)alkyl. Synthesized peptide derivatives are tachykinin antagonists. EFFECT: improved method of synthesis.